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DHEA Prior to Ovarian Stimulation appears not to affect IVF Outcomes in Women with Diminished Ovarian Reserve.

July 23, 2015

DHEA Prior To Ovarian Stimulation Appears Not To Affect IVF Outcomes In Women With Diminished Ovarian Reserve.
No one has really offered a great explanation for DHEA improving pregnancy in patients with diminished ovarian reserve (DOR). Initial reports were positive but most came from one center marketing nationally for these patients. If a patient had DHEA and gets pregnant, she will be convinced of course it was the DHEA that made the difference? In our world, if a suggestion is made and then patients get hold of it and spread the word on the internet, it is short order for it to be discussed in every RE practice in the country. DHEA made just such an initial splash. Before long it was the talk at the national meetings. There was a great deal of skepticism early on and I wonder if it’s just that with DHEA, programs that normally would have shuttled to egg donor were then giving patients wth DOR a chance at IVF and had some pregnancies which was “enlightening” to them. Of course we want to implicate the treatment but was it just reality and really a message that we should give patients with DOR a chance to try IVF?? Food for thought …………… the final answer is still to be determined.

Michael D. Fox, MD
Jacksonville Center
Reproductive Medicine

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