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Estrogen therapy linked to……

August 27, 2015

Dr. Fox responds to the following article:

http://www.pm360online.com/estrogen-therapy-linked-to-brain-atrophy-in-women-with-diabetes/

This study, from the WHI data set is a perfect example of the problems with the overall study.  The patients could not participate if they were on hormone replacement at the beginning of the study so we are starting with average age of 70 and adding estrogen.  When we turn the lights back on, the brain doesn’t work well either and is likely the reason cognition declined in the other WHI cognition studies.  The author’s incorrectly however discuss the “transition” of menopause and the loss of estrogen implying that it relates to these patients.  The patients were at least 15 years postmenopausal, so the transition had already occurred.  This study also points out how complicated these findings can be and if one merely reads the tag line, the results would be completely misleading.
What really matters and the ? we need answered is if women take hormones as soon as estrogen declines, what is the cognitive effect.  Our clinical opinion is that it is dramatically improves and is protective against loss of cognitive function.  
Michael D. Fox, MD
Jacksonville Center
Reproductive Medicine
jcrm.org 

   
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