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Injectable Gonadotropins

Injectable Gonadotropins are hormone medications that represent the same hormone the brain produces to stimulate the ovaries to make eggs. By utilizing these drugs throughout the first half of the menstrual cycle, more eggs than the usual one or two will be recruited and stimulated to develop. The basis for this therapy is to increase the available eggs, and thereby the chance of a normal fertilization and pregnancy is increased.

With injectable drug therapy we are relying on natural ovulation and the tubes to pick up the eggs for fertilization. This therapy also requires functional sperm. Therefore, couples with significant tubal or male factor issues are not good candidates for this therapy.

Injectable ovulation drugs are given for approximately 9 days in the early cycle. Patients are monitored in the office every 2-4 days and adjustments are made to the drug dose based on ultrasound findings and estradiol blood measurements. When follicles reach maturity, hCG is given as an ovulation trigger and either intrauterine insemination (IUI) or natural intercourse scheduled. Since an unknown number of eggs ovulate in response to hCG, this therapy creates an unknown risk for multiple pregnancy. This is in contrast to IVF where the number of transferred embryos can be controlled.

Injectable ovulation drug cycles are more agressive than oral or hybrid cycles. The pregnancy rates with these cycles range from 12-30% per cycle. This compares with 20% for normal fertlile couples on a per cycle basis. As with other cycle types, our nursing staff meets with patients before the cycle starts to provide a schedule and  instruction on drug administration. This therapy is intense and often patients feel that they are on an emotional roller coaster. We strive to provide this therapy to you in a caring and compassionate atmosphere.