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Progesterone May Not Prevent Recurrent Miscarriage, Study Finds.

December 1, 2015

The results of this study underscore what we have been trying to tell patients for years. Progesterone “deficiency” or low progesterone is simply a marker for poor follicular development. The follicle develops in the first two weeks of the cycle before ovulation and progesterone peaks 7 days after ovulation and stays up if pregnancy is established. The progesterone is produced by the remnants of the ruptured follicle wall called the corpus luteum (hence the luteal phase). This finding of low progesterone in the luteal phase promted physicians in the past to prescribe progesterone to “fix” the low level. The problem is that the egg has long since ovulated and the damage is done to the egg development phase of the cycle and the egg itself and all the progesterone in the world won’t fix that issue. We hope that this study gains traction and the focus of treatment for these patients is shifted from the luteal phase to the follicular (egg development) phase of the cycle. If you have been treated with progesterone for this problem, we don’t feel that this has any negative impact on the chance of a successful pregnancy.

Dr. Michael Fox

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